QuantiFERON Gold vs. 2-Step PPD TB: Key Difference

Occupational Health

For Employers

Table of Contents

2 Step PPD (TB Skin Test) QuantiFERON Gold (TB Blood Test)

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Preventing TB is essential to public health and to the welfare of people who may be at risk of developing it severely. One of the primary ways of preventing TB’s spread is testing for it; however, many Americans don’t know the difference between the two kinds of tests. Here are the two types of TB tests and their important differences:

2 Step PPD (TB Skin Test)

A TB skin test is used to find out if you have TB germs in your system. In order to get this test administered, a healthcare worker injects a small amount of fluid called tuberculin (or PPD) into your arm. There is often light swelling where the test is administered and after a few days, you must return to have the test read by a doctor. A positive test means that you are infected with TB germs, but further tests are required to discern whether the person has LTBI or TB. A positive test generally comes with some sort of reaction to the test, where a negative test doesn’t hold that observation. Recent exposure may turn up a false negative, so making sure to return 8-10 weeks after you were exposed is imperative to getting the right result. However, if both tests turn out to be negative, you likely don’t have TB.

QuantiFERON Gold (TB Blood Test)

TB Blood tests require a blood sample to be taken for the practitioner to determine whether there are TB germs in a person’s system. There are two TB blood tests approved by the FDA:

If the test turns out to be positive, another test must be administered to determine whether the TB germs are from LTBI (latent TB infect) or the TB disease. If negative, you likely don’t have it. These tests are available from concierge services like Vitable and from physical offices like the health department or the doctor’s office. The sample is sent to a lab for analysis and the results are generally delivered digitally.

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